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This crucial vitamin plays a vital role in energy production, nerve function, and overall cellular health
When present, the hematologic manifestations of vitamin B12 deficiency include macrocytic anemia with macro-ovalocytes and macro-erythrocytes (or macrocytes), hypersegmentation of neutrophil nuclei, variable polychromasia, neutropenia, and megaloblastic changes in the bone marrow
Published human trials report minimal adverse events at doses ranging from 50mg to 100mg daily over 12 weeks, with the most common findings being mild gastrointestinal discomfort (812% of participants) and transient headache (57%)
Hydroxocobalamin is the NICE-recommended, prescription-only form of B12 used by the NHS
Some people choose to get injections or infusions regularly to maintain immune system support
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