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10.1007/s00401-019-02010-2 4 AlfaidiM.BarkerR
Its downstream signaling through PI3K/Akt/mTOR and MAPK/ERK makes it relevant to a wide range of research questions in muscle biology, bone physiology, neuroprotection, and metabolic signaling
People with severe acne have lower GSH levels and greater levels of oxidative stress in their blood, which might be a contributing factor to their frequent outbreaks
Activation of the PPAR pathway negatively affects fat formation by downregulating the expression of genes associated with new fat formation
Indeed, chronic ROS can cause protein oxidation of methionine and cysteine residues 112,113 , which in the absence of GSH becomes permanent and might decrease irreversibly CI and CII functionality
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