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Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]
10.1002/hep.25656
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This structural adjustment has been explored for its potential to retain certain functional properties of FOXO4 while exhibiting a longer stability profile in research settings
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