8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years
Sauve AA et al
B., Oreskovic, I., Ziger, T., Novinscak, T., Krezic, I., Strbe, S., Drinkovic, M., Brkic, F., Popic, J., Skrtic, A., Seiwerth, S., Staresinic, M., Sikiric, P.,
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