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In the STEP 1 clinical trial (NEJM, 2021), participants on semaglutide 2.4 mg lost an average of 14.9% of body weight at 68 weeks (about 33.6 lbs from a 232 lb average baseline) vs 2.4% with placebo
Tirzepatide activates both GLP-1 and GIP pathways, while semaglutide primarily activates the GLP-1 pathway
Cravings dont mean the drug isnt working
And the treatment involved diet soda
Importantly, TNF type 1 receptor knockout mice are resistant to the initiation and progression of NAFLD in response to both high-carbohydrate and methionine- and choline-deficient diets 26,27
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