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GraphPad Prism was used to calculate the area under the curve (AUC) for both parameters with or without 5FU, and then the difference in AUC was calculated as (AUC +5FU) (AUC 5FU)

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it is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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2: The volume of plasma (blood cells) is diluted by one time