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A new 2026 study clarifies the muscle loss issue
& De, A
Pulendran, B., S Arunachalam, P
It produces more modest results than semaglutide or tirzepatide, typically around 8 percent body weight loss, but it was the first GLP-1 to receive FDA approval specifically for weight management and remains a viable option for patients who prefer a shorter-acting medication or who experience intolerable side effects on the more potent formulations
Who should not take a GLP-1, full stop The boxed warning converts into a hard rule for a specific group
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