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When ARA-290 binds to the innate repair receptor, it initiates a cascade of downstream effects that shift the local immune environment from damage mode to repair mode

Deep vein thrombosis and pulmonary embolism, which involve unwanted clot formation in veins, are also managed within hematology

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P-gp participates in the formation of tumor cell membranes and can increase the net negative charge of the cell surface, so it is helpful for AMPs that possess positive charges to combine with the drug-resistant tumor cell membrane under electrostatic attraction

These include tissue factor pathway inhibitor, antithrombin, heparin, and proteins C and S (which are also vitamin K-dependent)