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For liraglutide, semaglutide, and tirzepatide, the top 2 most common exclusion criteria were major depressive disorder (17.4%, 17.4%, and 17.3%, respectively) and malignant neoplasms (7.6% for all) The third most common were uncontrolled hypertension (3.7%) for liraglutide, suicidal ideation (3.4%) for semaglutide, and liver disease (6.1%) for tirzepatide The least common exclusion was antiobesity medication use across all medications, at 0.6% for liraglutide and semaglutide and 0.5% for tirzepatide Trials of tirzepatide had the most overall exclusion criteria, at all of the exclusion criteria that were evaluated The study authors also noted that close to a third of US adults who do not have diabetes but were eligible to receive these medications were excluded from trials of their safety and efficacy, and that this is not the only patient population who may be underrepresented

The availability of oral formulations addresses patient preferences for non-injectable medications while the entry of additional manufacturers beyond the current duopoly is expected to improve supply availability and create pricing competition that will facilitate broader access

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Though it has potential side effects, glutathione can be safe for long-term skin use if used responsibly

But critics fear the FDAs stamp of approval will simply legitimize the use of unproven substances whose dangers may only become apparent in coming years