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Here, we leveraged human genetic data, dysmetabolic rodent models, humanized experimental models, toxicology studies and a phase 1 clinical trial to evaluate the tolerability and efficacy of TLC-2716, an orally administered LXR inverse agonist, which to date has not been tested in humans 19,29
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143(4):e30
YXH2024YS039), and Research Fund of Qianfoshan Hospital (grant no
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