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Weight loss itself improves insulin sensitivity and can lower thyroid hormone requirements by 1025%, meaning your levothyroxine dose may eventually need to decrease

This focus led to significant breakthroughs, but it became clear in animal models that single-pathway stimulation had a ceiling effect regarding metabolic stabilization and lipid management

Weight often returns after stopping the medication, indicating the need for ongoing lifestyle support, including healthy eating and physical activity

10.1371/journal.pone.0027260 12 ChenH.MorrisM

Dietary and lifestyle factors : Clinical trials are conducted alongside dietary counselling