L-acetylcarnitine in the treatment of patients with peripheral neuropathies : a short term, double-blind clinical study of 426 patients

FDA-labeled warnings include: Risk of thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) Pancreatitis (report severe abdominal pain, with or without vomiting) Gallbladder disease (including gallstones and cholecystitis) Acute kidney injury secondary to dehydration from gastrointestinal symptoms Hypoglycemia when used with insulin or insulin secretagogues (dose adjustments may be needed) Diabetic retinopathy complications in patients with type 2 diabetes and pre-existing retinopathy Suicidal behavior and ideation (monitor for depression or suicidal thoughts) Intestinal obstruction/ileus (particularly with severe constipation) These medications are contraindicated during pregnancy and should be discontinued at least two months before a planned pregnancy

Since exenatide is the only available GLP-1 receptor agonist covered by insurance in Turkey, a drug desensitization protocol, the only therapeutic method in hypersensitivity reactions used in case of absence of an alternative drug, was considered
Chamomile, ginger, and peppermint teas are especially effective, as they soothe the digestive tract and help reduce gas formation
Recently, the newly approved once-weekly subcutaneous GLP-1 receptor agonist semaglutide was reported to have potent effects on hyperglycemia and body weight and to reduce cardiovascular risk compared to a placebo [15]