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By use of micropuncture studies in rats with adriamycin-induced nephrotic syndrome, they could demonstrate that IGF-1 serum concentrations are markedly reduced and IGF-1 is highly ultrafiltrated together with IGFBP-2 appearing in proximal tubular fluid [217]

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers

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Women also tend to have lower baseline creatine stores than men, which means they may benefit disproportionately from supplementation