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Oral semaglutide works by activating GLP-1 receptors in the brain, reducing hunger, and promoting a sense of fullness, while also slowing gastric emptying to prolong satiety
Not incretin mimetics
Lancet (2017) 389(10085):2163
Tirzepatide also outperforms single-agonist medications in head-to-head comparisons, which is why researchers are so interested in how it compares to both semaglutide and newer triple agonists like retatrutide
Duan, H., Wang, L., Huangfu, M
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