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Whilst certain studies do hint at possible direct effects of thiazide, thiazide-like and loop diuretics on glucose homeostasis, and that its control is apparently beneficial for some aspects of the MetS, it is clear that additional research is necessary to fully understand the specific mechanisms involved and the potential clinical implications that they may have in hypertensive individuals with chronic metabolic conditions

doi: 10.1002/jat.2914 50 PachtE

Huang C, Zeng T, Li J, Tan L, Deng X, Pan Y, et al

Unlike minoxidil, where discontinuation typically leads to loss of gains within months, PTD-DBM may produce more durable results because it promotes actual neogenesis, the creation of new follicles, rather than simply maintaining existing ones in a state of artificial stimulation

By circumventing the stomach and digestive tract, the patient can also avoid such side effects