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Adequate protein intake (1.6g/kg minimum) remains the primary determinant of muscle retention

Biopsy can be helpful even in early stages if the diagnosis is uncertain, but it is more definitive in later stages with the hallmark manifestations of full-thickness necrosis and subepidermal detachment

The most common side effects include mild injection site reactions, occurring in approximately 8-12% of patients according to safety data from multiple clinical trials

New approaches include drugs that inhibit OXPHOS, induce oxidative stress, or disrupt the mitochondrial membrane potential to selectively eliminate cancer cells