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A very large fraction of published binding constants for melanocortin ligands, including those for cyclic analogues, peptidomimetics and candidate subtype-selective compounds, are reported as inhibition of I-NDP-alpha-MSH binding to membranes from cell lines stably expressing a single human receptor subtype

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At the same time, decreased values of GABA, a moderation of the neurotransmitters, and increased levels of myoinositol have been determined

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