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PubMed laboratory research record [PMID: 24666754] PubMed record related to this compound for laboratory literature review
According to our current understanding of GLP-1RAs mitochondrial regulatory effect and oxidative stress suppression ability on eye diseases, the molecular pathways mainly involve the PINK1/Parkin-mediated mitophagy pathway and the GLP-1R-ERK1/2-HDAC6 signaling pathway (see Figure 3)
Bax-induced caspase activation and apoptosis via CytochromecRelease from mitochondria is inhibitable by bcl-xL
Trials are needed to compare the clinical effect on symptoms and nerve regeneration
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