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Clinical trials typically report adverse events that occur above a certain threshold frequency (often 5% or greater) or those deemed clinically significant

These Kupffer cell effects were also associated with hepatocellular damage in rats and Guinea pigs, however this finding was not observed in the Rhesus monkeys, suggesting that species differences are an important factor in PGN toxicity

Genotyping Genomic DNA was isolated from blood samples (Puregene Systems, Gentra)

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