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*Correspondence: Jian Zhou, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

While this metabolic effect supports weight management, the primary driver of GLP-1mediated weight loss is reduced calorie intake rather than a substantial increase in energy expenditure

This multi-target drug design provides patients with more treatment options, making the drug's effect more comprehensive and long-lasting

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Anderson and colleagues reported that approximately 11.5% of patients experienced gastrointestinal side effects, though specific discontinuation rates attributable to these events were not consistently reported (94)