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The combination of reduced food intake (from tirzepatide), stimulant effects (from phentermine), and rapid body composition changes can create psychological stress that deserves attention alongside the physical monitoring

It typically takes about 48 weeks before changes in appetite and weight become apparent, and consistent loss tends to build over months as the medication reaches its optimal effect

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The price reduction also came amid pressure from the Trump administration to lower drug costs, with announcements about reduced pricing for Medicare, Medicaid, and the planned TrumpRx pharmaceutical program