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A common explanation is dehydration, which can occur due to gastrointestinal side effects such as nausea, vomiting, or diarrhoeaall frequently reported with GLP-1 receptor agonist therapies
Mean age at initiation of GLP-1 RA was 17.3 years, and duration of diabetes was 2 years
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The short half-life of active GLP-1 and GLP-2 of only a few minutes due to rapid degradation by dipeptidyl peptidase-4 (DPP4) 12 suggests a rather dynamic regulation of these proteins
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