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this is likely a gain-of-function variant that reduces BSEP and Mrp2 expression in hepatocytes [11]

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Patients with a history of pancreatitis, symptomatic gallbladder disease, or severe gastroparesis warrant careful discussion as well, since GLP-1s slow gastric emptying and can exacerbate these conditions

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The part that actually matters is where the research goes from here

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Diabetes (2003) 52:9

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