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A randomized, parallel-group, multicenter, phase 3 trial found that tirzepatide caused pancreatitis (5 mg n = 3, 10 mg n = 2, 15 mg n = 1) in patients with type 2 diabetes mellitus (Del Prato et al., 2021), and another double-blind, randomized, multicenter, phase 3 trial found that tirzepatide also caused pancreatitis (15 mg n = 2) in obese patients with type 2 diabetes mellitus (Garvey et al., 2023)

Others suggest its greatest value comes from indirect effects, like increased endurance , reduced muscle fatigue , and faster recovery , all of which contribute to a more consistent and effective training regimen

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