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[2] It has also been associated with higher rates of Down syndrome and birth defects in offspring of those with the MTHFR gene variation, as well as other issues that may manifest later on in life, such as an increased risk of blood clots and a higher risk of certain cancers

Pavan Kumar MA, Suresh D, Sneharani AH

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Early studies in vascular patients concluded that heterozygosity for the mutations T833C and G919A of the CBS gene was associated with an abnormal response to a methionine load, which was caused by the heterozygosity (Boers, 1997b

Glutathione, the body's master antioxidant, plays a critical role in neutralizing free radicals and supporting immune function, with intracellular concentrations declining with age and metabolic stress