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Last, to assess the impact of missing data, we included individuals who had been excluded due to missing BMI or HbA1c at baseline and applied mean imputation for BMI, HbA1c, systolic blood pressure, eGFR and ACR within each trial, then repeated analyses for cardiovascular, kidney, liver and safety outcomes

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This is crucial for optimal oxygen delivery throughout the body

In further research, it was found that berberine achieved antioxidant effects by reducing the expression of pro-inflammatory factors, apoptotic factors and nuclear transcription factor B (NF-b), as well as up-regulating the expression of peroxlsome proliferator-activated receptor- coactlvator-1 (PGC-1) and manganese superoxide dismutase