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Rose NR, Bonita R, Burek CL (2002) Iodine: an environmental trigger of thyroiditis

The most frequently reported side effects were gastrointestinal in nature, including nausea (occurring in 25-33% of patients depending on dose), diarrhea (21-23%), and vomiting (8-10%)

Those with longstanding diabetes and significant beta-cell exhaustion may experience more modest improvements, though Ozempic remains effective across the disease spectrum

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The mechanistic difference is important: semaglutide primarily addresses appetite regulation and metabolic signaling, while phentermine drives sympathetic activation