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Diener H-C, Tassorelli C, Dodick DW, Silberstein SD, Lipton RB, Ashina M, et al
These medications are contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN 2 syndrome, and require regular monitoring by a healthcare provider
With increasing cAMP levels, protein kinase A (PKA) and the exchange protein directly activated by cAMP-2 (Epac-2) are also activated
Formulations using cyanocobalamin instead of methylcobalamin require hepatic conversion before B12 becomes active, reducing bioavailability in some patients
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