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2 Mechanisms of action and ongoing therapeutic innovations in GLP-1 receptor agonists All GLP-1 RAs mimic the endogenous hormone GLP-1, binding to GLP-1 receptors (GLP-1 Rs) distributed in pancreatic islets, the gastrointestinal tract, and the brain
However, there were no significant differences between tirzepatide 5 mg and semaglutide 2 mg in terms of HbA1c and body weight reductions
At 48 weeks, the 8 mg group showed 22.8% mean body weight reduction, exceeding maximum tirzepatide dosing results
The article on how to get semaglutide at a lower cost covers cost reduction options in detail, and for many patients the math changes significantly when compounded options are part of the conversation
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