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Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

The concern is the proportion

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Common Side Effects The safety disclosures note that common side effects include nausea, vomiting, diarrhea, constipation, stomach pain, fatigue, and dizziness