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Considering the temporal nature of hypovolemia following increased semaglutide dosage, improvement of the ischemic colitis on the second colonoscopy following drug discontinuation, and lack of signs of infection during the initial admission, semaglutide was still deemed the most likely culprit of the colonic ischemia

These modifications make it approximately 3 times more potent and extend its half-life (20-30 hours) and duration of action

Control Portions: While tirzepatide helps reduce your appetite, its still important to be mindful of portion sizes

However, discontinuing semaglutide may lead to weight regain, emphasizing the importance of adopting lifestyle changes for lasting weight control

Indian J Exp Biol 2000;38:607-9