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The strongest human evidence is topical
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Hyperglycaemia differentially affects energy metabolism across kidney cell types, for example impeding glycolysis in glomerular epithelial cells (where glucose is the preferred energy substrate) while enhancing glycolysis in proximal tubular epithelial cells (which typically rely on fatty acid oxidation) [11]
doi: 10.1007/s10620-025-08964-6 104 AndersonSRAyoubMCoatsSMcHenrySTanTDeepakP
Emous, M., Wolffenbuttel, B
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