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Retatrutide binds to three receptors that regulate human energy metabolism: the GLP-1 receptor (appetite, insulin secretion, gastric emptying), the GIP receptor (insulin response, adipose handling), and the glucagon receptor (energy expenditure, hepatic lipid handling)

Understanding GLP-1 Weight Loss Medications GLP-1 receptor agonists work by mimicking hormones that regulate blood sugar and slow gastric emptying, which helps patients feel full longer and consume fewer calories

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At least one study has demonstrated semaglutide's ability to reduce osteoarthritis in people with obesity, possibly in part due to reductions in both weight and inflammation

And of course, we always recommend speaking with a professional