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Notably, over 99% of patients lost at least 5% of their body weight at 52 weeks, with nearly 48% losing more than 20%

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28,29,30 In our analysis biofilm cells upregulate the entire gene cassettes for pyrimidine ( BC3883-89 ) and purine ( BC0325-BC0332*) biosynthesis, as well as transporters of amino acid and formate synthesis required for nucleoside synthesis (BC0403*, BC0639, BC0640*, BC2383 , BC3939*, BC2790), nucleoside transporters ( BC2973, BC0363 ) and specific phosphate transporters ( BC4265-68 and BC0711 ), all molecules required for DNA synthesis