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Specific amino acid substitutions and a C18 fatty-acid side chain enhance albumin binding, reduce renal elimination, and confer resistance to DPP-4 degradation, extending its half-life to approximately one week and enabling once-weekly administration [14]

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doi: 10.1038/nature02440 107 LpezMLageRSahaAKPrez-TilveDVzquezMJVarelaLet al

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