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However, a small percentage of the population may still encounter problems from chronic acetaminophen usage or high doses

10.1016/S0140-6736(18)30478-1 Lancet 14 DomnguezC.LpezA.Ramos-CabrerP.Vieites-PradoA.Prez-MatoM.VillalbaC.et al (2019)

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The evidence is unambiguous: glutathione's antioxidant function depends entirely on the reduced thiol group remaining intact, and every hour above 8C or past the 28-day mark increases the probability that group has oxidised