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Connective tissue disorders such as Ehlers-Danlos syndrome also make skin and vessels more fragile, producing easy bruising and hyperflexible joints

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Eric Nager, M.D

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Usually, a patient notices an increase in stamina within a couple of days of the first injection

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A decreased appetite can lead to weight loss in the long term

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The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions

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