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In: Armstrong D, Stratton RD, editors

It takes part in the reduction of tocopheroloxyl radical (TocO) to -tocopherol with the appearance of an ascorbate radical (semidehydroascorbate): + + The ascorbate radical (A), in turn, is reduced to ascorbate (AN) with the help of reduced glutathione and the enzyme glutaredoxin: + 2GSH AH- + CSSG + + , as well as NADH-dependent semidihydroascorbine reductase: + NADH AH- + D+, and NADPH-dependent thioredoxin-reductase: + NADP AH- + NADP+ Reduced glutathione

Strict vegans who do not include two to three servings of fortified foods in their daily diet for those following a largely plant-based diet, foods that are fortified with vitamin B12, such as nutritional yeast, plant milks, spreads and breakfast cereals, make valuable additions to your diet

Patients should be aware that heavy, chronic ethanol use may counteract the therapeutic effects of vitamin B12