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Real-time stability test Conditions: Simulate actual storage conditions (such as in a cool place 20)
It's a fundamental shift from intervention to facilitation
A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]
Thalamotomy is less common than pallidotomy, with less than 5% of patients having the thalamus as the preferable target for thalamotomy or DBS [76]
This makes future dosing calculations incredibly simple
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