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Adverse Reactions/Side Effects The following adverse reactions are described, or described in greater detail, in other sections: - Primary pulmonary hypertension [see Warnings and Precautions (5.2)] - Valvular heart disease [see Warnings and Precautions (5.3)] - Effect on the ability to engage in potentially hazardous tasks [see Warnings and Precautions (5.5)] - Withdrawal effects following prolonged high dosage administration [see Drug Abuse and Dependence (9.3)] The following adverse reactions to phentermine have been identified: Cardiovascular Primary pulmonary hypertension and/or regurgitant cardiac valvular disease, palpitation, tachycardia, elevation of blood pressure, ischemic events