Notably, GLP-1RA liraglutide has been proven to repair lysosomal function and boost lysosomal biogenesis in HFD mice and hepatocytes by activating the transcription factor EB (TFEB), which is a vital regulator of lysosomal function [282]
Tirzepatide (Zepbound): Showed up to 20.9% average weight reduction at the highest dose in the SURMOUNT-1 trial
Zepbound is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg injection
Mice were humanely euthanized by CO inhalation followed by cervical dislocation as a secondary method when predefined humane endpoints were reached
Rather, it refers to organic sulfur compounds that occur naturally in protein-rich foods such as meat, fish, hard cheese, and milk, as well as in vegetables such as broccoli, garlic, and potatoes (2)