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ACMSD inhibition increased NAD + levels and improved mitochondrial homeostasis 302

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Hongwei Jiang: Conceptualization, Writing original draft, Writing review & editing, Supervision

Existing findings indicate that the protective mechanism is mainly attributed to the GLP-1 signaling pathway, which involves cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) and cAMP response element-binding protein (CREB)

Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide