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Because losing at least 5% of fasting body weight through lifestyle intervention during the 4- to 12-week run-in was a condition for their continued participation in the randomized treatment period, the results may not reflect those expected in the general population

The prevailing research view is that a dynamic imbalance between pro-inflammatory and anti-inflammatory cytokines may contribute to the pathogenesis of schizophrenia and subsequent psychopathological symptoms (193196)

These melanocortin-dopamine interaction studies have contributed to understanding of how melanocortin signalling modulates the mesolimbic reward system underlying motivated behaviour

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