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At doses of up to 30 micrograms per kilogram (g/kg), researchers noted that CJC-1295 DAC caused the following side effects: Mild injection site reactions Itching Headaches Pain Diarrhea Hypertension Induration The studys authors noted that around 70 percent of the test subjects who received CJC-1295 DAC experienced one or more of these side effects and that the severity of the reactions increased with doses over 30 g/kg

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It appears that the effects of gut permeability on immune activation and intestinal inflammation may vary, depending on the extent of mucosal barrier deregulation, and the context in which this occurs

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