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The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]
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In a study focused on the treatment of severe subarachnoid hemorrhage, intravenous administration of hydrogen-rich liquid was also employed
12 , 6269.e1 (2018)
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