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It has been reported that long-term oral carnitine treatment for 6 months in a patient with carnitine deficiency resulted in increased muscle strength, significant reduction in heart size, relief from cardiomyopathy, and partial repletion of carnitine levels in plasma and muscle with complete repletion of liver functions (71)
This reflects the ability to more intensively supplement physiological levels with GLP-1R agonists, rendering them the more powerful approach for treating obesity and type 2 diabetes
Feb 10, 2026 You are wasting semaglutide
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In the STEP-1 semaglutide trial, roughly 39% of the weight lost was lean mass in the DEXA substudy ( Wilding et al., NEJM 2021 )
