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However, it should be noted that serum urate concentrations vary markedly among different populations and the values are influenced by such things as age, sex, ethnicity, body weight, and the surface area of the body

A further consideration for women using tirzepatide (and potentially other incretin therapies) is the possible reduction in exposure to oral contraceptives, particularly around initiation and dose escalation

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Additionally, Phenylbutazone has excellent bioavailability (up to 90%) 111, 113 and long half-life (50-105 hrs) 111 , which may enable dose de-escalation, further decreasing risks

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