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Plaintiffs in this MDL allege that GLP-1 drugs increased the risk of NAION and that manufacturers failed to adequately warn patients and health care providers about this potential danger

They focused on adults with type 2 diabetes who had started either GLP-1 receptor agonists or metformin as their initial diabetes therapy

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Systematic review with meta-analysis: highly selective 5-HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation

The mechanism involves upregulation of matrix metalloproteinases (MMPs) and their inhibitors, which remodel collagen in a more organized way than unassisted healing