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5-12 The most common patient-reported adverse effects (AEs) associated with GLP-1 RAs and dual GIP/GLP-1 RAs are gastrointestinal (GI) in nature and may include abdominal pain, constipation, diarrhea, nausea, and vomiting
Both norepinephrine and epinephrine are stored in synaptic knobs of neurons that secrete it, however, epinephrine is not a mediator at postganglionic sympathetic nerve impulses
And it shifts fuel utilization away from glucose and toward stored fat
1997: Pollard et al
Activation of both GIP and GLP-1 receptors by retatrutide probably contributed to the observed changes in circulating triglycerides, as treatment with the dual GIP/GLP-1 receptor agonist tirzepatide significantly reduced triglyceride levels by up to 29% at 52 weeks in a clinical trial in people with T2D and MASLD 8
