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Anyone outside a healthy, monitored research context and especially anyone in one of the sensitive groups above sits entirely beyond the edge of what has been studied, which is exactly why a clinicians judgement, not a web page, is the right place for that decision to be made

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It is primarily involved in red blood cell formation and DNA synthesis

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This represents the lower end of the standard dose range and accounts for the theoretically reduced, though likely modest, contribution of hepatic clearance